Monoamine neurotransmitters modulate NT-3 levels in astrocytes
نویسنده
چکیده
Background Neurotrophin-3 (NT-3), a member of the neurotrophin family of neurotrophic factors, displays profound neuromodulatory functions in the normal and in the diseased brain. Under physiological conditions, NT-3 is produced by neuronal cells and also by local glial cells. We focused our investigation on the ability of astrocytes to synthesize NT-3 and, additionally, on the active involvement of the neurotransmitters noradrenaline, adrenaline, dopamine, histamine and serotonin (5-HT) in the regulation of NT-3 production in neonatal rat cortical astrocytes.
منابع مشابه
A 61 Histamine – neurotrophin - 3 interactions in cultured rat astrocytes
Background Neurotrophin-3 (NT-3) is produced by astrocytes, in addition to neurons, and monoamine neurotransmitters play a role in controlling NT-3 synthesis [1]. The impact of histamine on the regulation of NT-3 synthesis in cultured astrocytes has not been studied in detail. Therefore, we focused our present study on the active involvement of multiple histaminergic receptor and intracellular ...
متن کاملHistamine-neurotrophin-3 interactions in cultured rat astrocytes
Background Neurotrophin-3 (NT-3) is produced by astrocytes, in addition to neurons, and monoamine neurotransmitters play a role in controlling NT-3 synthesis [1]. The impact of histamine on the regulation of NT-3 synthesis in cultured astrocytes has not been studied in detail. Therefore, we focused our present study on the active involvement of multiple histaminergic receptor and intracellular ...
متن کاملGinsenoside Rb1 Modulates Level of Monoamine Neurotransmitters in Mice Frontal Cortex and Cerebellum in Response to Immobilization Stress
Cerebral monoamines play important roles as neurotransmitters that are associated with various stressful stimuli. Some components such as ginsenosides (triterpenoidal glycosides derived from the Ginseng Radix) may interact with monoamine systems. The aim of this study was to determine whether ginsenoside Rb1 can modulate levels of the monoamines such as dihydroxyphenylalanine (DOPA), dopamine (...
متن کاملThe role of nonneuronal neurotrophins in the brain
Background Neurotrophins (nerve growth factor, NGF; brain-derived neurotrophic factor, BDNF; neurotrophin-3, NT-3) are involved in various CNS functions from differentiation and neuron survival to synaptogenesis and synaptic plasticity. They are synthesized in neurons and also in nonenuronal cells (astrocytes), which therefore represent an important local source of trophic support in normal and...
متن کاملExcessive Astrocyte-Derived Neurotrophin-3 Contributes to the Abnormal Neuronal Dendritic Development in a Mouse Model of Fragile X Syndrome
Fragile X syndrome (FXS) is a form of inherited mental retardation in humans that results from expansion of a CGG repeat in the Fmr1 gene. Recent studies suggest a role of astrocytes in neuronal development. However, the mechanisms involved in the regulation process of astrocytes from FXS remain unclear. In this study, we found that astrocytes derived from a Fragile X model, the Fmr1 knockout (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009